Inhibition of urea-cycle activity by high concentrations of alanine.
نویسندگان
چکیده
1. Conditions are described in which high intracellular alanine concentrations inhibit urea-cycle flux in isolated hepatocytes. 2. Inhibition of urea-cycle flux by added alanine is DL-cycloserine-insensitive and is accompanied by an increase in intracellular citrulline and a decrease in ornithine. 3. Argininosuccinate synthetase (EC 6.3.4.5) activity in rat liver cytosol is inhibited by alanine in a competitive manner with respect to citrulline. It is concluded that this effects is the primary cause of inhibition of urea-cycle flux by alanine.
منابع مشابه
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ورودعنوان ژورنال:
- The Biochemical journal
دوره 186 1 شماره
صفحات -
تاریخ انتشار 1980